Shetty V P, Suchitra K, Uplekar M W, Antia N H
Foundation for Medical Research, Worli, Bombay, India.
Lepr Rev. 1997 Jun;68(2):131-8. doi: 10.5935/0305-7518.19970018.
As identified by a significant growth in the footpads of immunosuppressed mice, the incidence of viable bacteria in a group of 26 multibacillary (BL-LL) patients released from multidrug (MDT) treatment was found to be two times more in the nerves (46%) as compared to skin (23%). Evidently there was a positive correlation between the overall bacterial load and the incidence of viable organisms. Bacterial growth was also observed in two out of five cases where neither the skin nor the nerve homogenate had shown any presence of acid-fast bacilli. Histopathology of biopsies, skin as well as nerve, including those having viable bacteria did not show any features of active disease.
通过免疫抑制小鼠足垫的显著生长确定，在一组26名完成多药治疗（MDT）后出院的多菌型（BL-LL）患者中，神经中活细菌的发生率（46%）是皮肤中（23%）的两倍。显然，总体细菌载量与活生物体的发生率之间存在正相关。在五例皮肤和神经匀浆均未显示抗酸杆菌存在的病例中，有两例也观察到了细菌生长。活检的组织病理学检查，包括皮肤和神经，以及那些含有活细菌的组织，均未显示任何活动性疾病的特征。
