Zuñiga C, Palau T, Penin P, Gamallo C, de Diego J A
Chili University School of Medicine, Spain.
Trop Med Int Health. 1997 May;2(5):482-7.
We investigated the protective effect of Trypanosoma rangeli against infection with Trypanosoma cruzi in animal models of various ages and with different doses of inoculum. The age of the mice and the dose of parasites determined the course of the infection. When T. cruzi was inoculated into mice after challenge with T. rangeli, parasitaemia was more controlled, mortality decreased and histopathology showed lower inflammatory infiltration and pseudocysts. This study proposes a new murine model of the protective effect of recombinant proteins of T. rangeli for possible application in the vaccines field.
我们在不同年龄和不同接种剂量的动物模型中研究了兰氏锥虫对克氏锥虫感染的保护作用。小鼠的年龄和寄生虫剂量决定了感染的进程。当在经兰氏锥虫攻击后将克氏锥虫接种到小鼠体内时，寄生虫血症得到更好控制，死亡率降低，组织病理学显示炎症浸润和假囊肿减少。本研究提出了一种新的小鼠模型，用于研究兰氏锥虫重组蛋白的保护作用，可能应用于疫苗领域。
