Basso Beatriz, Castro Irma, Introini Virginia, Gil Patricia, Truyens Carine, Moretti Edgardo
Facultad de Ciencias Médicas, Universidad Nacional de Córdoba & Servicio Nacional de Chagas, Córdoba, Argentina.
Vaccine. 2007 May 10;25(19):3855-8. doi: 10.1016/j.vaccine.2007.01.114. Epub 2007 Mar 8.
The goal of this work was to test the efficacy of the vaccination with Trypanosoma rangeli in dogs. Mongrel dogs received three subcutaneous injections of fixed T. rangeli epimastigotes at 6-week intervals. Such immunisation induced antibodies against Trypanosoma cruzi. While both control and immunised dogs developed detectable parasitemia, this was lower and shorter in vaccinated animals. Interestingly, feeding of Triatoma infestans nymphs on vaccinated and chronically infected dogs led to a sharp reduction in the rate of bug infection. These results suggest that it might be possible to reduce the vectorial parasitemia through vaccination of dogs. As dogs are known to play a major role in the domestic cycle of T. cruzi, this might represent a strategy to reduce parasite transmission to humans.
这项工作的目的是测试用克氏锥虫疫苗接种犬的效果。杂种犬每隔6周皮下注射三次固定的克氏锥虫前鞭毛体。这种免疫诱导了针对克氏锥虫的抗体。虽然对照犬和免疫犬都出现了可检测到的寄生虫血症,但接种疫苗的动物体内的寄生虫血症较低且持续时间较短。有趣的是,用感染克氏锥虫的若虫叮咬接种疫苗的犬和慢性感染的犬,会导致臭虫感染率大幅降低。这些结果表明,通过给犬接种疫苗可能降低媒介寄生虫血症。由于已知犬在克氏锥虫的家庭传播循环中起主要作用,这可能是一种减少寄生虫传播给人类的策略。