Hardman C M, Baker B S, Lortan J, Breuer J, Surentheran T, Powles A, Fry L
Department of Dermatology, St Mary's Hospital, London, U.K.
Br J Dermatol. 1997 Jun;136(6):930-2.
We report the case of a patient with a long-standing history of widespread chronic plaque psoriasis, who was recently found to have a profound CD4+ lymphocytopenia. He is human immunodeficiency virus (HIV) negative. His psoriasis remains active and widespread, and he has had 60 cutaneous malignancies, including many squamous cell carcinomas, excised over the last 10 years. In the past he has had numerous cutaneous viral warts. Despite a low peripheral blood CD4+ T-cell count, similar numbers of activated T cells, identified by double labelling for CD4 and HLA-DR antigens, were found in the epidermis of our patient as other individuals with psoriasis. Thus, there appear to be sufficient activated CD4+ T cells in our patient's psoriatic plaques to maintain the psoriatic process.
我们报告了一例长期患有广泛慢性斑块状银屑病的患者，该患者最近被发现存在严重的CD4 +淋巴细胞减少症。他的人类免疫缺陷病毒（HIV）检测呈阴性。他的银屑病仍处于活动期且广泛存在，在过去10年中，他已切除了60处皮肤恶性肿瘤，包括许多鳞状细胞癌。他过去曾有大量皮肤病毒疣。尽管外周血CD4 + T细胞计数较低，但通过对CD4和HLA-DR抗原进行双重标记鉴定，在我们患者的表皮中发现的活化T细胞数量与其他银屑病患者相似。因此，在我们患者的银屑病斑块中似乎有足够的活化CD4 + T细胞来维持银屑病的病程。
