Fujimoto J, Ichigo S, Hirose R, Sakaguchi H, Tamaya T
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan.
Tumour Biol. 1997;18(4):206-12. doi: 10.1159/000218033.
To show the mRNA expressions of E-cadherin and alpha- and beta-catenin-which mainly compose the adherens junction-associated with invasion and metastasis of uterine cervical cancers, we studied the expression of E-cadherin and alpha- and beta-catenin mRNAs in cancers in comparison with normal counterparts. The integral expression of E-cadherin and alpha- and beta-catenin mRNAs was suppressed in the metastatic lesions of advanced uterine cervical cancers, while it was not in the primary tumors. Therefore, the suppressed expression of main adhesion molecules in the adherens junction might contribute to adherens-junctional dysfunction, which might lead to invasiveness and metastatic potential of advanced uterine cervical cancers as one rate-limiting step.
为了显示主要构成与子宫颈癌侵袭和转移相关的黏着连接的E-钙黏蛋白、α-连环蛋白和β-连环蛋白的mRNA表达，我们研究了E-钙黏蛋白、α-连环蛋白和β-连环蛋白mRNA在癌组织中的表达，并与正常对应组织进行比较。E-钙黏蛋白、α-连环蛋白和β-连环蛋白mRNA的整体表达在晚期子宫颈癌的转移灶中受到抑制，而在原发性肿瘤中则未受抑制。因此，黏着连接中主要黏附分子表达的抑制可能导致黏着连接功能障碍，这可能作为一个限速步骤导致晚期子宫颈癌的侵袭性和转移潜能。
