DNA对体外胶原蛋白原纤维形成有显著影响。
Marked effect of DNA on collagen fibrillogenesis in vitro.
作者信息
Kitamura H, Iwamoto C, Sakairi N, Tokura S, Nishi N
机构信息
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan.
出版信息
Int J Biol Macromol. 1997 Jun;20(3):241-4. doi: 10.1016/s0141-8130(97)00021-4.
Growth of collagen fibrils in the presence of DNA was more rapid than that in the absence of DNA. Some of collagen fibrils formed in the presence of DNA were significantly wider than those in the absence of DNA. Moreover, the cross-bandings were also very distinct in spite of using pepsin-digested collagen. These results suggest that DNA not only adsorbs to collagen but induces the extraordinary fibrillogenesis of collagen.
在DNA存在的情况下，胶原纤维的生长比不存在DNA时更快。在DNA存在的情况下形成的一些胶原纤维明显比不存在DNA时更宽。此外，尽管使用了胃蛋白酶消化的胶原蛋白，但其横纹也非常明显。这些结果表明，DNA不仅吸附到胶原蛋白上，还诱导胶原蛋白发生异常的原纤维形成。
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