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Repeated activation of neurotensin receptors sensitizes to the stimulant effect of amphetamine.

作者信息

Rompré P P

机构信息

Centre de Recherche de l'Hôpital du Sacré-Coeur et Département de Psychiatrie, Université de Montréal, Québec, Canada.

出版信息

Eur J Pharmacol. 1997 Jun 11;328(2-3):131-4. doi: 10.1016/s0014-2999(97)00159-3.

DOI:10.1016/s0014-2999(97)00159-3
PMID:9218694
Abstract

Effects of repeated intracerebroventricular microinjections of 18 nmol/10 microl of neurotensin, [D-Tyr11]neurotensin, or saline were tested on motor activity in different groups of rats. One week after the fourth central injection, sensitivity to the behavioral stimulant effect of amphetamine (1 mg/kg, i.p.) was tested. As previously reported, neurotensin attenuated motor activity while [D-Tyr11]neurotensin when compared to saline produced an initial suppression followed by an excitation. Despite such different behavioral effects, both peptides produced sensitization to the stimulant effect of amphetamine. These results show that repeated activation of neurotensin receptors produces long-lasting changes in responsiveness to a psychostimulant drug.

摘要

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