van Hoeven K H, Wanner J L, Ballas S K
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA.
Diagn Cytopathol. 1997 Jul;17(1):54-6. doi: 10.1002/(sici)1097-0339(199707)17:1<54::aid-dc11>3.0.co;2-9.
A diagnosis of fat emboli can be suspected in a patient presenting with the typical symptoms of the fat embolism syndrome, but is rarely proved pathologically, except at autopsy. We described a 25-yr-old man with sickle cell anemia who developed an infarctive crisis complicated by unexplained fever, neurologic change, and respiratory abnormalities. Blood drawn from the femoral vein and examined cytopathologically yielded necrotic bone marrow elements admixed with fat. The cytologic finding of fat emboli from necrotic bone marrow provided the diagnosis and helped guide subsequent medical intervention. This sample test is recommended for patients at risk for fat emboli to aid in the clinical diagnosis.
对于出现脂肪栓塞综合征典型症状的患者，可怀疑脂肪栓子的诊断，但除尸检外，很少能通过病理证实。我们描述了一名25岁的镰状细胞贫血男性患者，他发生了梗死危象，并伴有不明原因的发热、神经改变和呼吸异常。从股静脉抽取的血液进行细胞病理学检查，发现坏死的骨髓成分与脂肪混合。坏死骨髓中脂肪栓子的细胞学发现提供了诊断依据，并有助于指导后续的医疗干预。建议对有脂肪栓子风险的患者进行这种样本检测，以辅助临床诊断。
