Garza J A
Institute of Forensic Sciences, San Juán, Puerto Rico.
Am J Forensic Med Pathol. 1990 Mar;11(1):83-8. doi: 10.1097/00000433-199003000-00013.
A case of sickle cell disease diagnosed postmortem is described. A 37-year-old black woman presented with anemia, respiratory distress, and abdominal and back pain. Death followed an intramuscular injection of iron, and anaphylaxis was clinically diagnosed. At autopsy, massive fat and necrotic bone marrow embolization of pulmonary and renal vessels was found. In the vertebral column, multifocal areas of ischemic necrosis were present, and proved to be the source of this embolization. Sickled red cells appeared in bone marrow sinusoids, and signs of disseminated intravascular coagulation were present.
本文描述了一例死后诊断的镰状细胞病病例。一名37岁黑人女性出现贫血、呼吸窘迫以及腹部和背部疼痛。在肌肉注射铁剂后死亡，临床诊断为过敏反应。尸检发现肺和肾血管有大量脂肪和坏死骨髓栓塞。在脊柱中存在多灶性缺血性坏死，被证实是这种栓塞的来源。镰状红细胞出现在骨髓血窦中，并存在弥散性血管内凝血的迹象。
