非洛地平在妊娠中的应用。三例报告。
Felodipine use in pregnancy. Report of three cases.
作者信息
Casele H L, Windley K C, Prieto J A, Gratton R, Laifer S A
机构信息
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, Pennsylvania 15213-3180, USA.
出版信息
J Reprod Med. 1997 Jun;42(6):378-81.
BACKGROUND
Calcium channel blockers are effective agents for the management of chronic hypertension and are being used with increasing frequency. If their safety and efficacy during pregnancy can be documented, women can be counseled to continue their antihypertensive agent during pregnancy. To our knowledge, the use of felodipine, a calcium channel blocker of the dihydropyridine group, during pregnancy has not been described.
CASES
We report three cases of felodipine use in pregnancy by women with chronic hypertension.
CONCLUSION
In women with severe hypertension (diastolic blood pressure > 100 mm Hg) who require pharmacologic treatment of it during pregnancy, felodipine appears to be an acceptable option.
背景
钙通道阻滞剂是治疗慢性高血压的有效药物，且使用频率日益增加。如果能证明其在孕期的安全性和有效性，就可以建议女性在孕期继续服用其抗高血压药物。据我们所知，尚未有关于孕期使用二氢吡啶类钙通道阻滞剂非洛地平的相关描述。
病例
我们报告了3例慢性高血压女性在孕期使用非洛地平的病例。
结论
对于孕期需要药物治疗的重度高血压（舒张压>100 mmHg）女性，非洛地平似乎是一个可接受的选择。
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