Gardner M O, Goldenberg R L, Cliver S P, Boots L R, Hoffman H J
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, USA.
Acta Obstet Gynecol Scand Suppl. 1997;165:56-8.
To determine if maternal serum levels of human placental lactogen (hPL), estradiol, and pregnancy-specific beta 1-glycoprotein (SP1) measured at approximately 18 weeks' gestation were associated with fetal growth retardation (FGR) in infants delivered at or after 37 weeks.
Serum samples were obtained at a mean of 18 weeks' gestational age from 200 multiparous women with risk factors for FGR. Maternal serum concentrations of hPL, estradiol and SP1 were correlated with FGR.
A total of 59 (29.5%) of the 200 infants were diagnosed postnatally with FGR. There were no significant differences in the prevalence of FGR among the lowest quartiles of estradiol, hPL or SP1. However, pregnancies in the highest quartile of estradiol levels at 18 weeks' (> 580 pg/ml) were associated with a significantly lower risk of FGR than those in the lower three quartiles, 8 out of 50 (16%) vs 51 of 150 (34%) (p = < 0.05). The prevalence of FGR associated with the highest quartile of hPL (> 1.73 micrograms/ml) was 12.2% compared to 35% in the lower three quartiles (p = 0.025) and the prevalence of FGR associated with the highest quartile of SP1 (> 43 ng/ml) was 14% compared to 34.7% in the lower three quartiles (p = 0.018). Only one out of 21 infants (4.5%) whose mothers had each value in the highest quartile of hPL, estradiol, and SP1 was diagnosed with FGR compared to 58 out of 178 (32.6%) of the remaining infants (p = 0.007).
In pregnancies of women at high risk for FGR, higher levels of estradiol, hPL, and SP1 at 18 weeks are associated with a decreased prevalence of FGR. This finding indicates that high levels of these hormones are related to a lower risk of FGR, but that low levels do not predict FGR.
确定在妊娠约18周时检测的孕妇血清人胎盘催乳素（hPL）、雌二醇和妊娠特异性β1-糖蛋白（SP1）水平是否与37周及以后分娩的婴儿的胎儿生长受限（FGR）相关。
从200名有FGR危险因素的经产妇中，在平均妊娠18周时采集血清样本。将孕妇血清中hPL、雌二醇和SP1的浓度与FGR进行相关性分析。
200名婴儿中共有59名（29.5%）在出生后被诊断为FGR。雌二醇、hPL或SP1最低四分位数组中FGR的患病率无显著差异。然而，妊娠18周时雌二醇水平处于最高四分位数（>580 pg/ml）的孕妇发生FGR的风险显著低于较低的三个四分位数组，50名中的8名（16%）对比150名中的51名（34%）（p = <0.05）。hPL最高四分位数（>1.73微克/毫升）相关的FGR患病率为12.2%，而较低的三个四分位数组为35%（p = 0.025）；SP1最高四分位数（>43纳克/毫升）相关的FGR患病率为14%，而较低的三个四分位数组为34.7%（p = 0.018）。母亲的hPL、雌二醇和SP1均处于最高四分位数的21名婴儿中只有1名（4.5%）被诊断为FGR，其余178名婴儿中有58名（32.6%）（p = 0.007）。
在有FGR高风险的孕妇中，妊娠18周时较高水平的雌二醇、hPL和SP1与FGR患病率降低相关。这一发现表明这些激素水平高与FGR风险较低相关，但水平低并不能预测FGR。
