Chabielska E, Pawlak R, Buczko W
Department of Pharmacodynamics, Medical School, Białystok, Poland.
Acta Physiol Hung. 1996;84(3):271-2.
Platelet aggregation was studied in PRP upon stimulation with ADP and collagen in normotensive rats treated with losartan (10 mg/kg). The acute and subchronic (5 days) losartan administration did not change the aggregating response of rat platelets. Similarly, in vitro study aggregation of platelets remained unaltered following incubation with losartan and its active metabolite EXP3174. In this study we presented the lack of influence of losartan and its main metabolite on rat platelet aggregation in normotensive rats.
在用氯沙坦（10毫克/千克）治疗的正常血压大鼠中，研究了富血小板血浆（PRP）在ADP和胶原蛋白刺激下的血小板聚集情况。急性和亚慢性（5天）给予氯沙坦并未改变大鼠血小板的聚集反应。同样，在体外研究中，血小板与氯沙坦及其活性代谢物EXP3174孵育后，其聚集情况仍未改变。在本研究中，我们呈现了氯沙坦及其主要代谢物对正常血压大鼠血小板聚集无影响的情况。
