Ciampor F, Závodská E, Cmarko D, Cmarková J, Varecková E
Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Acta Virol. 1997 Apr;41(2):83-91.
Brefeldin A (BFA) decreased the expression of influenza A virus haemagglutinin (HA) and M2 protein on the plasma membrane of virus-infected MDCK cells. It caused a retention of M1 protein in the cell nucleus and a decrease of its expression on the plasma membrane. On the other hand, an increased labelling of the cytoplasmic domain of M2 protein on the plasma membrane in BFA-treated cells was observed in contrast to the labelling in BFA-untreated cells. The effects of BFA on the microtubules and cellular motors are discussed.
布雷菲德菌素A（BFA）降低了甲型流感病毒血凝素（HA）和M2蛋白在病毒感染的MDCK细胞膜上的表达。它导致M1蛋白滞留在细胞核中，并降低其在细胞膜上的表达。另一方面，与未用BFA处理的细胞中的标记相比，观察到在用BFA处理的细胞中，M2蛋白细胞质结构域在细胞膜上的标记增加。文中讨论了BFA对微管和细胞运动蛋白的影响。
