Chua Sonja Courtney Jun Hui, Cui Jianzhou, Engelberg David, Lim Lina Hsiu Kim
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Immunology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Front Microbiol. 2022 Apr 21;13:869406. doi: 10.3389/fmicb.2022.869406. eCollection 2022.
Annually, the influenza virus causes 500,000 deaths worldwide. Influenza-associated mortality and morbidity is especially high among the elderly, children, and patients with chronic diseases. While there are antivirals available against influenza, such as neuraminidase inhibitors and adamantanes, there is growing resistance against these drugs. Thus, there is a need for novel antivirals for resistant influenza strains. Host-directed therapies are a potential strategy for influenza as host processes are conserved and are less prone mutations as compared to virus-directed therapies. A literature search was performed for papers that performed viral-host interaction screens and the Reactome pathway database was used for the bioinformatics analysis. A total of 15 studies were curated and 1717 common interactors were uncovered among all these studies. KEGG analysis, Enrichr analysis, STRING interaction analysis was performed on these interactors. Therefore, we have identified novel host pathways that can be targeted for host-directed therapy against influenza in our review.
每年，流感病毒在全球导致50万人死亡。在老年人、儿童和慢性病患者中，与流感相关的死亡率和发病率尤其高。虽然有针对流感的抗病毒药物，如神经氨酸酶抑制剂和金刚烷类药物，但对这些药物的耐药性正在增加。因此，需要针对耐药流感毒株的新型抗病毒药物。宿主导向疗法是治疗流感的一种潜在策略，因为与病毒导向疗法相比，宿主过程是保守的，且不易发生突变。我们对进行病毒-宿主相互作用筛选的论文进行了文献检索，并使用Reactome通路数据库进行生物信息学分析。总共筛选了15项研究，在所有这些研究中发现了1717个共同相互作用分子。对这些相互作用分子进行了KEGG分析、Enrichr分析和STRING相互作用分析。因此，在我们的综述中，我们确定了可用于针对流感进行宿主导向治疗的新型宿主通路。
