Epand R M
Biochim Biophys Acta. 1977 Dec 15;471(3):412-20. doi: 10.1016/0005-2736(77)90046-3.
Fluorescence and circular dichroism spectra indicate that pentagastrin interacts with dimyristoyl glycerophosphocholine more strongly below the phase transition temperature of the lipid than above it. Studies on the interaction of several peptides with dimyristoyl glycerophosphocholine suggest that this property may be related to the ability of these peptides to form amphipathic structures containing two hydrophobic amino acids separated by two other amino acids. Pentagastrin has a marked effect on the proton magnetic resonance spectra of dipalmitoyl glycerophosphocholine below the phase transition temperature indicating the the peptide decreases the motional freedom of the lipid.
荧光光谱和圆二色光谱表明，在脂质的相变温度以下，五肽胃泌素与二肉豆蔻酰甘油磷酸胆碱的相互作用比在相变温度以上时更强。对几种肽与二肉豆蔻酰甘油磷酸胆碱相互作用的研究表明，这种特性可能与这些肽形成含有两个被另外两个氨基酸隔开的疏水氨基酸的两亲结构的能力有关。在相变温度以下，五肽胃泌素对二棕榈酰甘油磷酸胆碱的质子磁共振谱有显著影响，表明该肽降低了脂质的运动自由度。
