Muñoz de Toro M M, Luque E H
Department of Human Physiology, Faculty of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, Santa Fe, Argentina.
J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):277-84. doi: 10.1016/s0960-0760(96)00221-x.
Estrogen, through estrogen receptors (ERs), may regulate the synthesis of progesterone receptors (PRs) and of a heat shock estrogen receptor-associated protein (hsp27). In female breast carcinoma (FBC) both proteins serve as surrogate indicators for the presence of functional ERs. In addition, the expression of these proteins was related to other prognostic indicators of value in female breast tumours. Endocrine disorders, hormone therapy and altered estrogen metabolism have been associated with the development of male breast cancer (MBC), suggesting that evaluation of the expression of ER, PR and hsp27 might improve our understanding of the biology of this tumour. ER and PR status and hsp27 expression were evaluated by immunohistochemistry in 16 primary MBC patients. The interrelationships between these parameters were established and compared with the clinicopathological data on the tumours. Ten (56%) MBC patients were ER-positive, 69% were PR-positive and all samples were hsp27-positive. Our series of MBC patients showed a positive correlation between ERs and PRs, however there was a lack of correlation between hsp27 and ERs or PRs. MBCs did not exhibit any correlation between the biomarkers studied and known prognostic indicators for females (e.g. Scarff-Bloom-Richardson (SBR) or modified SBR (MSBR) grade, T stage, lymph node status). This is the first published series reporting the incidence of hsp27 in MBC. The lack of association between the expression of ERs and hsp27 found in MBC differs from the results reported for FBC, moreover the expression of ERs, PRs or hsp27 did not correlate with the clinicopathological parameters that have prognostic value in females. Although the data were obtained from a relatively small sample population, our findings suggest that MBC and FBC are biologically different tumours with respect to the expression of the studied proteins.
雌激素可通过雌激素受体（ERs）调节孕激素受体（PRs）以及热休克雌激素受体相关蛋白（hsp27）的合成。在女性乳腺癌（FBC）中，这两种蛋白均作为功能性ERs存在的替代指标。此外，这些蛋白的表达与女性乳腺肿瘤中其他有价值的预后指标相关。内分泌紊乱、激素治疗以及雌激素代谢改变均与男性乳腺癌（MBC）的发生有关，这表明评估ER、PR和hsp27的表达可能会增进我们对这种肿瘤生物学特性的理解。通过免疫组织化学方法对16例原发性MBC患者的ER和PR状态以及hsp27表达进行了评估。确定了这些参数之间的相互关系，并与肿瘤的临床病理数据进行了比较。10例（56%）MBC患者ER呈阳性，69%的患者PR呈阳性，所有样本hsp27均呈阳性。我们的MBC患者系列显示ERs和PRs之间呈正相关，然而hsp27与ERs或PRs之间缺乏相关性。MBC与所研究的生物标志物和已知的女性预后指标（如斯卡夫-布卢姆-理查森（SBR）或改良SBR（MSBR）分级、T分期、淋巴结状态）之间均无相关性。这是首次发表的报道MBC中hsp27发生率的系列研究。MBC中ERs表达与hsp27之间缺乏关联，这与FBC的报道结果不同，此外，ERs、PRs或hsp27的表达与对女性具有预后价值的临床病理参数无关。尽管数据来自相对较小的样本群体，但我们的研究结果表明，就所研究蛋白的表达而言，MBC和FBC是生物学特性不同的肿瘤。
