Bouchard C S, Meyer M A, McDonnell J F
Department of Ophthalmology, Loyola University Medical Center, Chicago, Illinois 60153, USA.
Cornea. 1997 Jul;16(4):480-2.
A 37-year-old Hispanic man with a history of chronic myelogenous leukemia was first seen with fever and preseptal cellulitis of this right orbit after a tooth extraction.
The patient subsequently developed bilateral, severe peripheral ulcerative keratitis. He was treated with systemic antibiotics for a presumed underlying infectious cause. Several painful, necrotizing skin lesions developed over his face, trunk, and extremities.
Repeated skin biopsies of the necrotizing lesions were consistent with pyoderma gangrenosum. Both the skin lesions and peripheral ulcerative keratitis responded dramatically to systemic prednisone.
Pyoderma gangrenosum should be included in the differential diagnosis of peripheral ulcerative keratitis.
一名37岁有慢性粒细胞白血病病史的西班牙裔男性，在拔牙后首次因发热和右眼眶隔前蜂窝织炎就诊。
该患者随后发展为双侧严重的周边溃疡性角膜炎。因推测有潜在感染原因，对其进行了全身性抗生素治疗。他的面部、躯干和四肢出现了几个疼痛性坏死性皮肤病变。
对坏死性病变进行的多次皮肤活检结果与坏疽性脓皮病相符。皮肤病变和周边溃疡性角膜炎对全身性泼尼松均有显著反应。
坏疽性脓皮病应列入周边溃疡性角膜炎的鉴别诊断范围。
