Mayes A R, Daum I, Markowisch H J, Sauter B
Department of Clinical Neurology, University of Sheffield, UK.
Cortex. 1997 Jun;33(2):197-217. doi: 10.1016/s0010-9452(08)70001-7.
An extensive battery of tests of anterograde amnesia and remote memory was given to ten amnesics with lesions either to the medial temporal lobes of the diencephalon. These showed that the patients had anterograde amnesia with deficits in verbal and non-verbal recall and recognition, but preservation of word stem completion and intelligence. Mild impairments on executive tests and digit span performance were largely caused by the poor performance of the Korsakoff patients. The amnesics also showed remote memory deficits for personal and public domain information, and temporal gradients were observed for some of the tests. These deficits probably arose because the patients' anterograde amnesia was more severe than their retrograde amnesia even for the recent pre-morbid past. They were more impaired in the recall of details about famous names in their ability to recognize such names. There was also a suggestion that performance on anterograde tests did not relate strongly to that on tests of retrograde amnesia of the remote pre-morbid past. However, this effect was less apparent with memory for personal information when the format and the information tapped were matched on pre- and post-morbid tests.
对十名患有间脑内侧颞叶损伤的遗忘症患者进行了一系列广泛的顺行性遗忘和远期记忆测试。结果显示，这些患者存在顺行性遗忘，在言语和非言语回忆及识别方面存在缺陷，但词干补全能力和智力得以保留。执行测试和数字广度表现的轻度受损在很大程度上是由科尔萨科夫综合征患者的不佳表现所致。遗忘症患者在个人和公共领域信息的远期记忆方面也存在缺陷，并且在一些测试中观察到了时间梯度。这些缺陷可能是因为即使对于发病前近期的情况，患者的顺行性遗忘也比逆行性遗忘更严重。他们在回忆著名人物名字的细节以及识别这些名字的能力方面受损更严重。还有迹象表明，顺行性测试的表现与发病前远期逆行性遗忘测试的表现没有强烈关联。然而，当发病前和发病后的测试在形式和所涉及的信息方面相匹配时，这种效应在个人信息记忆方面不太明显。
