Tsao H, Sober A J, Barnhill R L
Department of Dermatology, Harvard Medical School, Boston, MA, USA.
Semin Cutan Med Surg. 1997 Jun;16(2):131-6. doi: 10.1016/s1085-5629(97)80007-7.
Desmoplastic neurotropic melanoma (DNM) is a rare variant of a spindle cell melanoma. The majority of these tumors occur on the head and neck of elderly patients. The rather variable clinical appearance (e.g. frequent lack of pigmentation) makes initial diagnosis often difficult. Histologically, DNM may show a lentiginous melanocytic proliferation with atypia and pleomorphic spindle cells in the dermis. Immunostaining for S-100 is usually positive although staining for HMB-45 is frequently absent. As with other melanomas, surgery is the first line treatment for DNM. Unlike other melanomas, however, survival for DNM may be better compared with other forms of melanoma.
促纤维增生性嗜神经性黑色素瘤（DNM）是梭形细胞黑色素瘤的一种罕见变体。这些肿瘤大多发生在老年患者的头颈部。其临床表现相当多变（例如常有色素脱失），这使得初步诊断往往很困难。组织学上，DNM可能表现为伴有非典型性的雀斑样黑素细胞增生以及真皮内的多形性梭形细胞。S - 100免疫染色通常呈阳性，而HMB - 45染色常常缺失。与其他黑色素瘤一样，手术是DNM的一线治疗方法。然而，与其他形式的黑色素瘤不同，DNM患者的生存率可能更高。
