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[高压氧疗与抗聚集剂:对缺血性心脏病患者血小板功能的影响]

[Hyperbaric oxygenation and antiaggregants: effects on platelet function in patients with ischemic heart disease].

作者信息

Seriakov V V, Feofanova I D

出版信息

Anesteziol Reanimatol. 1997 Mar-Apr(2):31-3.

PMID:9221683
Abstract

Platelet function (duration and percentage of aggregation and disaggregation) was studied in 65 chronic coronary patients over the course of hyperbaric oxygenation and antiaggregant therapy. A course of hyperbaric oxygenation (8 to 12 sessions at absolute atmosphere of 1.3-1.6 for 40 min) had no proaggregant or antiaggregant effects on the platelets in this category of patients. Aspirin in a daily dose of 125 mg and pentoxifylline in a daily dose of 300 mg reliably decreased the percentage of platelet aggregation and increased the share of disaggregation. Hyperbaric oxygenation in the above mode did not change the antiaggregant activity of these drugs.

摘要

在65名慢性冠状动脉疾病患者接受高压氧治疗和抗血小板聚集治疗的过程中,对其血小板功能(聚集和解聚的持续时间及百分比)进行了研究。一个疗程的高压氧治疗(在绝对气压1.3 - 1.6下进行8至12次治疗,每次40分钟)对这类患者的血小板没有促聚集或抗聚集作用。每日剂量为125毫克的阿司匹林和每日剂量为300毫克的己酮可可碱可可靠地降低血小板聚集百分比并增加解聚比例。上述模式的高压氧治疗并未改变这些药物的抗聚集活性。

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