Pramanik A K, Hansen R C
Arch Dermatol. 1979 Oct;115(10):1224-5. doi: 10.1001/archderm.1979.04010100044018.
A premature, malnourished infant had seizures and abnormal neurological function associated with topical gamma benzene hexachloride (lindane) therapy. The level of gamma benzene hexachloride in his blood was 17 times greater than expected after a single topical application of 1% gamma benzene hexachloride. Significant levels developed in another child's blood after repeated applications of small amounts to areas of dermatitis and excoriations on the skin. The use of topical gamma benzene hexachloride in pediatric patients is reviewed because of increased evidence of unpredictable absorption and toxicity.
一名早产、营养不良的婴儿在接受外用γ-六氯环己烷（林丹）治疗时出现癫痫发作和神经功能异常。单次外用1%γ-六氯环己烷后，其血液中γ-六氯环己烷的水平比预期高17倍。另一名儿童在反复少量外用该药于皮肤的皮炎和擦伤部位后，血液中也出现了显著的药物水平。鉴于有越来越多的证据表明外用γ-六氯环己烷的吸收和毒性不可预测，因此对儿科患者外用γ-六氯环己烷的使用情况进行了综述。
