Genuis Stephen J, Lane Kevin, Birkholz Detlef
University of Alberta, Edmonton, AB, Canada T6G 2R7; University of Calgary, Calgary, AB, Canada T2N 4N1.
Department of Chemistry, The King's University, Edmonton, AB, Canada T6B 2H3.
Biomed Res Int. 2016;2016:1624643. doi: 10.1155/2016/1624643. Epub 2016 Oct 5.
. Many individuals have been exposed to organochlorinated pesticides (OCPs) through food, water, air, dermal exposure, and/or vertical transmission. Due to enterohepatic reabsorption and affinity to adipose tissue, OCPs are not efficiently eliminated from the human body and may accrue in tissues. Many epidemiological studies demonstrate significant exposure-disease relationships suggesting OCPs can alter metabolic function and potentially lead to illness. There is limited study of interventions to facilitate OCP elimination from the human body. This study explored the efficacy of induced perspiration as a means to eliminate OCPs. . Blood, urine, and sweat (BUS) were collected from 20 individuals. Analysis of 23 OCPs was performed using dual-column gas chromatography with electron-capture detectors. . Various OCPs and metabolites, including DDT, DDE, methoxychlor, endrin, and endosulfan sulfate, were excreted into perspiration. Generally, sweat samples showed more frequent OCP detection than serum or urine analysis. Many OCPs were not readily detected in blood testing while still being excreted and identified in sweat. No direct correlation was found among OCP concentrations in the blood, urine, or sweat compartments. . Sweat analysis may be useful in detecting some accrued OCPs not found in regular serum testing. Induced perspiration may be a viable clinical tool for eliminating some OCPs.
许多人通过食物、水、空气、皮肤接触和/或垂直传播接触到有机氯农药（OCPs）。由于肝肠循环再吸收以及对脂肪组织的亲和力，OCPs无法有效地从人体中清除，可能会在组织中蓄积。许多流行病学研究表明，暴露与疾病之间存在显著关联，这表明OCPs会改变代谢功能，并有可能导致疾病。关于促进人体清除OCPs的干预措施的研究有限。本研究探讨了诱导排汗作为清除OCPs的一种方法的效果。从20名个体中采集了血液、尿液和汗液（BUS）。使用带有电子捕获检测器的双柱气相色谱法对23种OCPs进行了分析。各种OCPs及其代谢产物，包括滴滴涕（DDT）、滴滴伊（DDE）、甲氧滴滴涕、异狄氏剂和硫丹硫酸盐，都通过汗液排出。一般来说，汗液样本中检测到OCPs的频率高于血清或尿液分析。许多OCPs在血液检测中不易检测到，但仍会通过汗液排出并被识别。在血液、尿液或汗液成分中的OCPs浓度之间未发现直接相关性。汗液分析可能有助于检测常规血清检测中未发现的一些蓄积的OCPs。诱导排汗可能是清除某些OCPs的一种可行的临床工具。
