Arnold R, Pflieger H, Dietrich M, Heimpel H
Blut. 1977 Nov 22;35(5):405-14. doi: 10.1007/BF00996627.
Patients with severe granulocytopenia of different origin received granulocyte transfusions. The migration and phagocytic ability of the transfused granulocytes in the oral cavity ("orogranulocytes") served as a parameter for measuring the viability of the granulocytes in vivo. There was no difference between granulocytes collected by continuous flow centrifugation and those collected by filtration leukapheresis. Under the influence of the transfusion treatment mucous membrane ulcers (MMU) subsided and healed. Where ulcers were present the number of orogranulocytes (OG) increased after granulocyte transfusion. In addition there was a significant correlation between the number of granulocytes in the peripheral blood and the number of orogranulocytes. As a control, orogranulocytes were studied in a group of healthy persons with intact teeth, toothless persons with normal blood counts and one patient with an acute agranulocytosis.
不同病因导致的严重粒细胞减少症患者接受了粒细胞输注。输注的粒细胞在口腔中的迁移和吞噬能力（“口腔粒细胞”）作为衡量粒细胞在体内活力的参数。连续流式离心采集的粒细胞与过滤白细胞单采术采集的粒细胞之间没有差异。在输血治疗的影响下，黏膜溃疡（MMU）消退并愈合。存在溃疡的部位，粒细胞输注后口腔粒细胞（OG）数量增加。此外，外周血粒细胞数量与口腔粒细胞数量之间存在显著相关性。作为对照，在一组牙齿完好的健康人、血常规正常的无牙者以及一名急性粒细胞缺乏症患者中研究了口腔粒细胞。
