• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Transformation-related expression of a low-molecular-mass tropomyosin isoform TM5/TM30nm in transformed rat fibroblastic cell lines.低分子量原肌球蛋白亚型TM5/TM30nm在转化大鼠成纤维细胞系中的转化相关表达
J Cancer Res Clin Oncol. 1997;123(6):331-6. doi: 10.1007/BF01438309.
2
Decreased expression of a single tropomyosin isoform, TM5/TM30nm, results in reduction in motility of highly metastatic B16-F10 mouse melanoma cells.单一原肌球蛋白亚型TM5/TM30nm的表达降低，导致高转移性B16-F10小鼠黑色素瘤细胞的运动性降低。
Biochem Biophys Res Commun. 1996 Aug 14;225(2):427-35. doi: 10.1006/bbrc.1996.1190.
3
Cloning and characterization of a novel zinc finger protein (MDZF) that is associated with monocytic differentiation of acute promyelocytic leukemia cells.一种与急性早幼粒细胞白血病细胞单核细胞分化相关的新型锌指蛋白（MDZF）的克隆与鉴定
J Cancer Res Clin Oncol. 2001 Nov;127(11):659-67. doi: 10.1007/s004320100266.
4
Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.来自致瘤性人成纤维细胞的编码转化敏感原肌球蛋白同工型3的cDNA的克隆与鉴定
Mol Cell Biol. 1988 Jan;8(1):160-8. doi: 10.1128/mcb.8.1.160-168.1988.
5
Molecular cloning of a unique complementary DNA of rat myosin regulatory light chain and its elevated expression in v-src-transformed rat culture cell lines.
Cell Growth Differ. 1993 Nov;4(11):939-45.
6
Human fibroblast tropomyosin isoforms: characterization of cDNA clones and analysis of tropomyosin isoform expression in human tissues and in normal and transformed cells.人成纤维细胞原肌球蛋白异构体：cDNA克隆的特性及人组织、正常细胞与转化细胞中原肌球蛋白异构体表达分析
Cell Motil Cytoskeleton. 1993;25(3):267-81. doi: 10.1002/cm.970250307.
7
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.系统性药理学治疗慢性斑块状银屑病：网络荟萃分析。
Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD011535. doi: 10.1002/14651858.CD011535.pub4.
8
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.慢性斑块状银屑病的全身药理学治疗：一项网状Meta分析。
Cochrane Database Syst Rev. 2020 Jan 9;1(1):CD011535. doi: 10.1002/14651858.CD011535.pub3.
9
Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.染色体臂 1p 和 19q 缺失的检测在胶质瘤患者中的诊断准确性和成本效益。
Cochrane Database Syst Rev. 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2.
10
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.慢性斑块状银屑病的全身药理学治疗：一项网状荟萃分析。
Cochrane Database Syst Rev. 2017 Dec 22;12(12):CD011535. doi: 10.1002/14651858.CD011535.pub2.

引用本文的文献

1
Developmental Profiling of Tropomyosin Expression in Mouse Brain Reveals Tpm4.2 as the Major Post-synaptic Tropomyosin in the Mature Brain.小鼠大脑中肌钙蛋白表达的发育谱分析揭示Tpm4.2是成熟大脑中主要的突触后肌钙蛋白。
Front Cell Neurosci. 2017 Dec 22;11:421. doi: 10.3389/fncel.2017.00421. eCollection 2017.
2
The actin cytoskeleton as a sensor and mediator of apoptosis.肌动蛋白细胞骨架作为细胞凋亡的传感器和介质。
Bioarchitecture. 2012 May 1;2(3):75-87. doi: 10.4161/bioa.20975.
3
Interior decoration: tropomyosin in actin dynamics and cell migration.室内装饰：原肌球蛋白在肌动蛋白动力学和细胞迁移中的作用。
Cell Adh Migr. 2011 Mar-Apr;5(2):181-6. doi: 10.4161/cam.5.2.14438. Epub 2011 Mar 1.
4
Tetratricopeptide repeat domain 9A is an interacting protein for tropomyosin Tm5NM-1.四肽重复结构域9A是原肌球蛋白Tm5NM-1的一种相互作用蛋白。
BMC Cancer. 2008 Aug 12;8:231. doi: 10.1186/1471-2407-8-231.
5
Calponin h1 suppresses tumor growth of Src-induced transformed 3Y1 cells in association with a decrease in angiogenesis.钙调蛋白h1通过减少血管生成来抑制Src诱导的转化3Y1细胞的肿瘤生长。
Jpn J Cancer Res. 2002 Aug;93(8):935-43. doi: 10.1111/j.1349-7006.2002.tb01340.x.

本文引用的文献

1
Decreased expression of a single tropomyosin isoform, TM5/TM30nm, results in reduction in motility of highly metastatic B16-F10 mouse melanoma cells.单一原肌球蛋白亚型TM5/TM30nm的表达降低，导致高转移性B16-F10小鼠黑色素瘤细胞的运动性降低。
Biochem Biophys Res Commun. 1996 Aug 14;225(2):427-35. doi: 10.1006/bbrc.1996.1190.
2
Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene.转导的原肌球蛋白1 cDNA的表达抑制了由ras癌基因转化的细胞的肿瘤生长。
Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7039-43. doi: 10.1073/pnas.90.15.7039.
3
Identification of novel alternatively spliced isoforms of the tropomyosin-encoding gene, TMnm, in the rat cochlea.大鼠耳蜗中肌动蛋白结合蛋白编码基因TMnm新型可变剪接异构体的鉴定。
Gene. 1994 Jun 10;143(2):251-6. doi: 10.1016/0378-1119(94)90105-8.
4
Isolation of a yeast tropomyosin-related cDNA clone that encodes a novel transmembrane protein having a C-terminal highly basic region.
Biochem Biophys Res Commun. 1994 Mar 30;199(3):1363-71. doi: 10.1006/bbrc.1994.1381.
5
Restoration of microfilament bundle organization in v-raf-transformed NRK cells after transduction with tropomyosin 2 cDNA.用原肌球蛋白2 cDNA转导后，v-raf转化的NRK细胞中微丝束组织的恢复。
Cancer Lett. 1994 Nov 25;87(1):47-53. doi: 10.1016/0304-3835(94)90408-1.
6
Human fibroblast tropomyosin isoforms: characterization of cDNA clones and analysis of tropomyosin isoform expression in human tissues and in normal and transformed cells.人成纤维细胞原肌球蛋白异构体：cDNA克隆的特性及人组织、正常细胞与转化细胞中原肌球蛋白异构体表达分析
Cell Motil Cytoskeleton. 1993;25(3):267-81. doi: 10.1002/cm.970250307.
7
Motility and adhesive properties of high- and low-metastatic murine neoplastic cells.高转移性和低转移性小鼠肿瘤细胞的运动性和黏附特性
Cancer Res. 1984 Feb;44(2):811-24.
8
Structural and functional properties of the non-muscle tropomyosins.非肌肉原肌球蛋白的结构和功能特性
Mol Cell Biochem. 1983;57(2):127-46. doi: 10.1007/BF00849190.
9
Differential expression of tropomyosin forms in the microfilaments isolated from normal and transformed rat cultured cells.原肌球蛋白形式在从正常和转化的大鼠培养细胞中分离出的微丝中的差异表达。
J Biol Chem. 1983 Nov 25;258(22):13954-64.
10
Lack of tropomyosin correlates with the absence of stress fibers in transformed rat kidney cells.原肌球蛋白的缺失与转化的大鼠肾细胞中应力纤维的缺失相关。
Biochim Biophys Acta. 1982 Apr 29;720(2):154-62. doi: 10.1016/0167-4889(82)90007-6.

低分子量原肌球蛋白亚型TM5/TM30nm在转化大鼠成纤维细胞系中的转化相关表达

Transformation-related expression of a low-molecular-mass tropomyosin isoform TM5/TM30nm in transformed rat fibroblastic cell lines.

作者信息

Miyado K, Sato M, Taniguchi S

机构信息

Department of Molecular and Developmental Science, Tokai University, Ischara, Japan.

出版信息

J Cancer Res Clin Oncol. 1997;123(6):331-6. doi: 10.1007/BF01438309.

DOI:10.1007/BF01438309
PMID:9222299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12201513/
Abstract

We cloned a full-length rat TM5/TM30nm cDNA. Using this cDNA as a probe, we demonstrated that expression of TM5/TM30nm mRNA was higher in the tumorigenic rat fibroblastic cell lines SR-3Y1-2 and fos-SR-3Y1-202 than in the normal cell line 3Y1. High expression of TM5/TM30nm protein in SR-3Y1-2 and fos-SR-3Y1-202 cells was also detected by Western blot analysis using anti-TM5/TM30nm antiserum. In addition, the cellular localization of this protein differed between 3Y1 cells and tumorigenic ones. These findings suggest that TM5/TM30nm is involved in malignant transformation of rat fibroblastic cells.

摘要

我们克隆了大鼠TM5/TM30nm的全长cDNA。以该cDNA为探针，我们证明，在致瘤性大鼠成纤维细胞系SR-3Y1-2和fos-SR-3Y1-202中，TM5/TM30nm mRNA的表达高于正常细胞系3Y1。使用抗TM5/TM30nm抗血清进行蛋白质免疫印迹分析，也检测到SR-3Y1-2和fos-SR-3Y1-202细胞中TM5/TM30nm蛋白的高表达。此外，该蛋白在3Y1细胞和致瘤性细胞中的细胞定位有所不同。这些发现表明，TM5/TM30nm参与大鼠成纤维细胞的恶性转化。