静脉麻醉药对家兔心血管系统的影响。
The effects of intravenous anaesthetics on the cardiovascular system of the rabbit.
作者信息
McGrath J C, MacKenzie J E
出版信息
Br J Pharmacol. 1977 Oct;61(2):199-212. doi: 10.1111/j.1476-5381.1977.tb08405.x.
Abstract
1 A pithed rabbit preparation is described that allows selective stimulation of the vertebral outflows. 2 The responses to stimulation of sympathetic vasopressor fibres were blocked by hexamethonium and phentolamine but potentiated by cocaine, whereas the responses to stimulation of cardioaccelerator fibres were blocked by propranolol. 3 Ketamine, althesin and pentobarbitone enhanced the effects of noradrenaline and attenuated the effects of sympathetic nerve stimulation. Thiopentone enhanced the effects of both noradrenaline and sympathetic nerve stimulation. 4 In pithed rabbits a transient, dose-related cardiovascular depression was produced by each agent irrespective of whether vasomotor tone was present whereas in decerebrate rabbits the corresponding cardiovascular depression was longer lasting. 5 It is concluded that the cardiovascular depression produced by intravenous anaesthetics in intact rabbits is due to a combination of central and peripheral effects.
摘要
- 描述了一种可选择性刺激脊柱传出神经的脊髓麻醉兔制备方法。2. 六甲铵和酚妥拉明可阻断对交感缩血管纤维刺激的反应，但可卡因可增强该反应，而普萘洛尔可阻断对心脏加速纤维刺激的反应。3. 氯胺酮、阿法沙龙和戊巴比妥可增强去甲肾上腺素的作用并减弱交感神经刺激的作用。硫喷妥钠可增强去甲肾上腺素和交感神经刺激的作用。4. 在脊髓麻醉兔中，无论是否存在血管运动张力，每种药物均可产生与剂量相关的短暂心血管抑制，而在去大脑兔中，相应的心血管抑制持续时间更长。5. 得出结论，完整兔静脉麻醉药产生的心血管抑制是中枢和外周效应共同作用的结果。
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