在脊髓横断大鼠中，α,β-亚甲基ATP对血管升压反应和输精管反应的阻断作用。
Blockade of vasopressor and vas deferens responses by alpha,beta-methylene ATP in the pithed rat.
作者信息
Bulloch J M, McGrath J C
机构信息
Autonomic Physiology Unit, University of Glasgow.
出版信息
Br J Pharmacol. 1988 May;94(1):103-8. doi: 10.1111/j.1476-5381.1988.tb11504.x.
Abstract
- The pressor responses produced by the intravenous administration of alpha,beta-methylene ATP were tachyphylactic. 2. alpha,beta-Methylene ATP can attenuate pressor responses to sympathetic nerve stimulation both in the presence and in the absence of alpha-adrenoceptor blocking agents. 3. alpha,beta-Methylene ATP has no effect on the pressor responses produced by bolus injections of noradrenaline. 4. In the presence of alpha-adrenoceptor blocking agents, alpha,beta-methylene ATP further attenuates contractions of the vas deferens produced by nerve stimulation. 5. The results, together with previous data, suggest that the vasopressor response to stimulation of the sympathetic outflow in the rat is partly purinergic and partly alpha-adrenergic and that this occurs as co-transmission. The same applies to rat vas deferens, confirming in vitro data. The pithed rabbit had an alpha-blocker-resistant vasopressor nerve-mediated response but this was resistant to alpha,beta-methylene ATP.
摘要
- 静脉注射α,β-亚甲基ATP所产生的升压反应具有快速耐受性。2. 无论有无α-肾上腺素能受体阻断剂存在，α,β-亚甲基ATP均可减弱对交感神经刺激的升压反应。3. α,β-亚甲基ATP对去甲肾上腺素推注所产生的升压反应无影响。4. 在α-肾上腺素能受体阻断剂存在的情况下，α,β-亚甲基ATP可进一步减弱神经刺激所引起的输精管收缩。5. 这些结果与先前的数据共同表明，大鼠交感神经传出刺激所引起的血管升压反应部分是嘌呤能的，部分是α-肾上腺素能的，且这是以共同传递的方式发生的。这同样适用于大鼠输精管，证实了体外实验数据。去大脑兔具有一种对α-阻滞剂有抗性的血管升压神经介导反应，但这种反应对α,β-亚甲基ATP有抗性。
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1
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Eur J Pharmacol. 1983 Aug 19;92(1-2):161-3. doi: 10.1016/0014-2999(83)90126-7.
2
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Eur J Pharmacol. 1984 Apr 13;100(1):85-90. doi: 10.1016/0014-2999(84)90318-2.
3
Separation of adrenergic and non-adrenergic contractions to field stimulation in the rat vas deferens.大鼠输精管中肾上腺素能和非肾上腺素能收缩对场刺激的分离。
Br J Pharmacol. 1983 Jun;79(2):379-93. doi: 10.1111/j.1476-5381.1983.tb11010.x.
4
Cotransmitters in the motor nerves of the guinea pig vas deferens: electrophysiological evidence.豚鼠输精管运动神经中的共递质：电生理证据。
Science. 1982 Nov 12;218(4573):693-5. doi: 10.1126/science.6291151.
5
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J Physiol. 1984 Feb;347:561-80. doi: 10.1113/jphysiol.1984.sp015083.
6
Discrete events measure single quanta of adenosine 5'-triphosphate secreted from sympathetic nerves of guinea-pig and mouse vas deferens.离散事件测量从豚鼠和小鼠输精管交感神经分泌的三磷酸腺苷的单个量子。
Neuroscience. 1984 Sep;13(1):21-8. doi: 10.1016/0306-4522(84)90256-2.
7
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8
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10
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