Haugan K, Petersen J S, Spannow J, Shalmi M, Christensen S
Department of Pharmacology, University of Copenhagen, Denmark.
J Hypertens. 1997 Jul;15(7):775-82. doi: 10.1097/00004872-199715070-00010.
That non-natriuretic doses of loop diuretics exert an antihypertensive action has been suggested, but not confirmed, by simultaneous measurements of the arterial pressure and sodium balance during therapy.
To examine the relationship between changes in arterial pressure and changes in sodium balance during furosemide treatment.
Twenty hypertensive Dahl salt-sensitive rats fed a 4% NaCl diet were allocated to four groups and administered the following treatments: placebo once a day intraperitoneally, continuous infusion of 4 mg/day furosemide intraperitoneally, 4 mg furosemide once a day intraperitoneally and 12 mg furosemide once every third day intraperitoneally.
The mean arterial pressure (MAP) was measured continuously with radiotelemetry and the sodium balance was measured with the rats in metabolic cages.
Administration of furosemide as a bolus injection once a day (P < 0.01) or once every third day (P < 0.05) lowered the MAP significantly compared with placebo, whereas continuous infusion of furosemide had no significant effect on the MAP (P < 0.07). Fast Fourier transformation analysis detected an acute antihypertensive action related to the temporary diuretic and natriuretic responses during the period 0-6 h after intraperitoneal bolus injections of 4 and 12 mg furosemide. None of the treatment regimens produced 24 h sodium or potassium losses. At the end of the study, the total body water, extracellular fluid volume, total body sodium and potassium were similar for rats in all groups.
Furosemide has an acute antihypertensive action in Dahl salt-sensitive rats fed a 4% NaCl diet that is related to renal sodium and volume losses whereas the long-term antihypertensive effect is independent of changes in extracellular fluid volume, total body water, sodium and potassium.
有研究提示，袢利尿剂的非利钠剂量具有降压作用，但在治疗过程中通过同时测量动脉压和钠平衡尚未得到证实。
研究速尿治疗期间动脉压变化与钠平衡变化之间的关系。
将20只喂食4%氯化钠饮食的高血压Dahl盐敏感大鼠分为四组，给予以下处理：每天一次腹腔注射安慰剂；每天持续腹腔注射4毫克速尿；每天一次腹腔注射4毫克速尿；每三天一次腹腔注射12毫克速尿。
用无线电遥测法连续测量平均动脉压（MAP），并将大鼠置于代谢笼中测量钠平衡。
与安慰剂相比，每天一次（P<0.01）或每三天一次（P<0.05）推注速尿可显著降低MAP，而持续输注速尿对MAP无显著影响（P<0.07）。快速傅里叶变换分析检测到，腹腔推注4毫克和12毫克速尿后0至6小时内，与短暂的利尿和利钠反应相关的急性降压作用。所有治疗方案均未导致24小时钠或钾丢失。在研究结束时，所有组大鼠的总体水、细胞外液量、总体钠和钾相似。
速尿对喂食4%氯化钠饮食的Dahl盐敏感大鼠具有急性降压作用，这与肾钠和容量丢失有关，而长期降压作用与细胞外液量、总体水、钠和钾的变化无关。
