RNA作为药物靶点。
RNA as a drug target.
作者信息
Pearson N D, Prescott C D
机构信息
Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park (North), Third Avenue, Harlow, Essex, CM19 5AW, UK.
出版信息
Chem Biol. 1997 Jun;4(6):409-14. doi: 10.1016/s1074-5521(97)90192-7.
PMID:9224569
Abstract
Historically, the pharmaceutical industry has focused on proteins, rather than nucleic acids, as drug targets. But recent advances in the fields of RNA synthesis, structure determination and therapeutic target identification make the systematic exploitation of RNA as a drug target a realistic goal.
摘要
从历史上看，制药行业一直将蛋白质而非核酸作为药物靶点。但RNA合成、结构测定和治疗靶点识别领域的最新进展使将RNA作为药物靶点进行系统开发成为一个现实目标。
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