结节病中分枝杆菌DNA的存在。

Presence of mycobacterial DNA in sarcoidosis.

作者信息

Popper H H, Klemen H, Hoefler G, Winter E

机构信息

Institute of Pathology and Laboratory of Environmental and Respiratory Pathology, University of Graz, Medical School, Austria.

出版信息

Hum Pathol. 1997 Jul;28(7):796-800. doi: 10.1016/s0046-8177(97)90152-0.

DOI:10.1016/s0046-8177(97)90152-0

PMID:9224747

Abstract

In 11 of 35 clinically proven cases of sarcoidosis, we detected DNA sequences coding for the mycobacterial 65-kDa antigen. In four cases, the sequences were homologous to Mycobacterium avium; seven sequences were related to other nontuberculous Mycobacteria. The insertion sequence 1110, characteristic for Mycobacterium avium, was present in three cases. The insertion sequence 6110 of the Mycobacterium tuberculosis complex (M tuberculosis, africanum, bovis, BCG) was not detectable in any of the 11 cases, ruling out the presence of members of the Mycobacterium tuberculosis complex. Therefore, it seems reasonable to speculate about a mycobacterial cause in some cases of sarcoidosis.

摘要

在35例经临床证实的结节病病例中，我们在11例中检测到了编码分枝杆菌65-kDa抗原的DNA序列。在4例中，这些序列与鸟分枝杆菌同源；7个序列与其他非结核分枝杆菌有关。鸟分枝杆菌特有的插入序列1110在3例中出现。结核分枝杆菌复合体（结核分枝杆菌、非洲分枝杆菌、牛分枝杆菌、卡介苗）的插入序列6110在这11例中均未检测到，排除了结核分枝杆菌复合体成员的存在。因此，推测在某些结节病病例中存在分枝杆菌病因似乎是合理的。