Hallagan J B, La Du B N, Pariza M W, Putnam J M, Borzelleca J F
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0626, USA.
Food Chem Toxicol. 1997 Jun;35(6):625-32. doi: 10.1016/s0278-6915(97)00018-5.
Cassia gum is approved for use in Europe by the Commission Directive (EEC No. E 499) and is listed in the Annex of the Council Directive (70/524/EEC) as a stabilizer (thickening and gelling agent) in the manufacture of canned pet foods (for cats and dogs). It is also approved for use in Japan and is listed as a food additive in The Ministry of Health and Welfare Announcement No. 160 (10 August 1995). A panel of experts in the areas of toxicology, pharmacology and food science was assembled to review the safety of cassia gum for use as a thickening agent in human and pet foods in the United States. The available data on cassia gum and structurally related gums demonstrate a lack of toxic effects in animals. This review is the basis for the consideration of cassia gum as generally recognized as safe (GRAS) under conditions of its intended use as a thickening agent in human and pet foods.
决明胶已获欧盟委员会指令（EEC No. E 499）批准在欧洲使用，并被列入理事会指令（70/524/EEC）附件，作为罐装宠物食品（猫和狗食用）生产中的稳定剂（增稠剂和胶凝剂）。它在日本也获批准使用，并被列入厚生省公告第160号（1995年8月10日）中的食品添加剂名单。美国组建了一个由毒理学、药理学和食品科学领域专家组成的小组，以审查决明胶作为增稠剂用于人类和宠物食品的安全性。关于决明胶及结构相关胶的现有数据表明，其在动物身上没有毒性作用。本次审查是将决明胶在按预期用作人类和宠物食品增稠剂的条件下视为一般认为安全（GRAS）的依据。
