Ieni J R, Gold R M
Brain Res Bull. 1977 Sep-Oct;2(5):367-74. doi: 10.1016/0361-9230(77)90070-3.
When pituitaries are intact, hypothalamic knife cuts produce obesity in adult rats but not in weanlings. Knife cut weaning females do not usually begin to become obese until after they are 7 weeks old. When pituitaries are removed, symmetrical or asymmetrical knife cuts produce obesity promptly in both adults and weanlings. Obesity indices that correct for stunted linear growth reveal that in adults the degree of obesity is independent of the presence or absence of the pituitary. Based on these findings we speculate that there may be two appetite regulating systems, a juvenile one involving the pituitary, and an adult one involving the hypothalamus.
当垂体完整时，下丘脑刀割会使成年大鼠肥胖，但对断奶幼鼠无效。刀割断奶雌性大鼠通常直到7周龄后才开始肥胖。当切除垂体时，对称或不对称的刀割都会使成年大鼠和断奶幼鼠迅速肥胖。校正生长发育迟缓后的肥胖指数显示，在成年大鼠中，肥胖程度与垂体的有无无关。基于这些发现，我们推测可能存在两种食欲调节系统，一种是涉及垂体的幼年系统，另一种是涉及下丘脑的成年系统。
