Sclafani A, Gale S K, Springer D
Physiol Behav. 1975 Jul;15(1):63-70. doi: 10.1016/0031-9384(75)90280-2.
Parasagittal knife cuts through the perifornical hypothalamus either medial or lateral to the fornix produced hyperphagia and obesity and altered the rat's ingestive responses to dilute glucose solutions. The lateral knife cut rats drank less dilute glucose solution under both nondeprived and food deprived conditions and displayed less of a feeding suppressive response to glucose ingestion compared to controls. The lateral cut rats were also deficient in their feeding response to insulin-induced hypoglycemia, although their altered sensitivity to glucose and insulin did not appear to be causally related. The medial knife cuts decreased the responsivity to glucose, but less so than the lateral cuts, and did not alter the ingestive response to insulin. Both the medial and lateral knife cuts did not appear to change the rat's responsivity to concentrated blucose solutions. The neuroanatomical and functional nature of the disorder responsible for these effects and its relationship to the hyper-phagia-obesity syndrome are discussed.
矢状旁切穿过穹窿内侧或外侧的穹窿周下丘脑，会导致食欲亢进和肥胖，并改变大鼠对稀释葡萄糖溶液的摄食反应。与对照组相比，外侧刀切断的大鼠在非饥饿和饥饿条件下饮用的稀释葡萄糖溶液都较少，并且对葡萄糖摄入的摄食抑制反应也较小。外侧切断的大鼠对胰岛素诱导的低血糖的摄食反应也存在缺陷，尽管它们对葡萄糖和胰岛素的敏感性改变似乎没有因果关系。内侧刀切断降低了对葡萄糖的反应性，但比外侧切断的程度小，并且没有改变对胰岛素的摄食反应。内侧和外侧刀切断似乎都没有改变大鼠对浓缩葡萄糖溶液的反应性。本文讨论了导致这些效应的疾病的神经解剖学和功能性质及其与食欲亢进-肥胖综合征的关系。
