Tuccari G, Rossiello R, Barresi G
Department of Human Pathology, University of Messina, Italy.
Histol Histopathol. 1997 Jul;12(3):671-6.
By immunohistochemistry, the presence of major iron-binding proteins (lactoferrin, transferrin, ferritin) has been investigated in adenocarcinomas (27 cases), adenosquamous carcinoma (1 case), undifferentiated sarcomatoid carcinoma (1 case) and mucinous adenocarcinomas (3 cases) of the gallbladder 10 samples of chronic lithyasic cholecystitis, 4 adenomyomas and 6 tubulo-villous adenomas have also been studied. In a variable share of adenocarcinomas, a positive immunoreactivity for iron-binding antisera was encountered in the cytoplasm, while tubulo-villous adenomas, adenomyomas and the normal epithelium of the gallbladder were generally unreactive. In carcinomatous lesions, the staining intensity was variable between different cases or individual tumour cells. The production of these iron-binding proteins in the gallbladder carcinoma in itself could be related to a greater availability of iron for metabolic processes in the neoplastic cell; alternatively, the cytoplasmic localization of these substances in carcinomatous elements may be a consequence of a defective or impaired function of iron-binding receptors with a modified degree of transmembranous iron transfer.
通过免疫组织化学方法，对胆囊腺癌（27例）、腺鳞癌（1例）、未分化肉瘤样癌（1例）和黏液腺癌（3例）中主要铁结合蛋白（乳铁蛋白、转铁蛋白、铁蛋白）的存在情况进行了研究。还对10份慢性结石性胆囊炎样本、4例腺肌瘤和6例管状绒毛状腺瘤进行了研究。在不同比例的腺癌中，细胞质中铁结合抗血清呈阳性免疫反应，而管状绒毛状腺瘤、腺肌瘤和胆囊正常上皮通常无反应。在癌性病变中，不同病例或单个肿瘤细胞之间的染色强度各不相同。胆囊癌中这些铁结合蛋白的产生本身可能与肿瘤细胞代谢过程中铁的可利用性增加有关；或者，这些物质在癌性成分中的细胞质定位可能是铁结合受体功能缺陷或受损以及跨膜铁转运程度改变的结果。
