Okamoto Y, Tominaga K, Uemura S, Matsuoka H, Tsujii T, Nakano H
Department of Clinico-Laboratory Diagnostics, Nara Medical University, Japan.
J Atheroscler Thromb. 1995;2(1):66-9. doi: 10.5551/jat1994.2.66.
A 41-year-old female patient with muscle dystrophy, hepatosplenomegaly and tendinous xanthoma showed mild hypertriglyceridemia. The lipoprotein profile in blood showed increases in triglycerides in VLDL and LDL, and a marked decrease of cholesterol in HDL. Chylomicronemia was found, but was not severe. Both lipoprotein lipase and hepatic triglyceride lipase activities were reduced to a level that was only a few percent of the control. Immunoblotting study revealed that the IgG autoantibody in her serum was apparently reactable with hepatic triglyceride lipase and weakly with lipoprotein lipase. Hypertriglyceridemia in this patient is suggested to be due to the autoantibody to these lipases.
一名41岁患有肌肉萎缩症、肝脾肿大和肌腱黄色瘤的女性患者出现轻度高甘油三酯血症。血液中的脂蛋白谱显示极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）中的甘油三酯增加，而高密度脂蛋白（HDL）中的胆固醇显著降低。发现有乳糜微粒血症，但并不严重。脂蛋白脂肪酶和肝甘油三酯脂肪酶的活性均降至仅为对照水平百分之几的程度。免疫印迹研究显示，她血清中的IgG自身抗体明显可与肝甘油三酯脂肪酶反应，与脂蛋白脂肪酶反应较弱。该患者的高甘油三酯血症被认为是由于针对这些脂肪酶的自身抗体所致。
