Malkova O N, Kuzmin P I, Potts R
Frumkin Institute of Electrochemistry, Russian Academy of Sciences, Moscow, Russia.
Membr Cell Biol. 1997;10(5):601-11.
Two models of electrohydration of stratum corneum (SC) have been developed. In the first model, the hydration of one interbilayer region is considered on the assumption that water molecules are adsorbed on the inhomogeneous surface of a bilayer and can interact, thereby lowering their energy on the surface. The dependence of the hydration degree on the voltage across the skin had been found. At certain parameter values the degree of hydration rapidly grows at certain voltage up to the magnitudes at which continuous water pathways appear. The second model has used the macroscopic approach which presumes water to be present in the interbilayer region as microdrops. The dependence of the hydration degree on voltage has been also found. At voltages of the order of tens of volts the obtained hydrations of interbilayer regions are sufficient to generate electroinduced hydrophilic pores in the SC lipid phase. Formation of tortuous continuous pathways for the transport of small ions is little probable because it requires voltages much higher than 100 V. We suggest that small ions pass the skin by the straight way through corneocytes and lipid bilayers at voltages of the order of tens of volts and higher.
已经开发出两种角质层（SC）电水合模型。在第一个模型中，基于水分子吸附在双层的不均匀表面上且能相互作用从而降低其表面能量这一假设，考虑了一个双层间区域的水合作用。已经发现水合程度与皮肤两端电压的关系。在某些参数值下，水合程度在特定电压下迅速增长，直至出现连续水通道的程度。第二个模型采用了宏观方法，假定双层间区域中的水以微滴形式存在。也发现了水合程度与电压的关系。在几十伏量级的电压下，所获得的双层间区域的水合作用足以在SC脂质相中产生电诱导的亲水性孔。形成用于小离子传输的曲折连续通道的可能性很小，因为这需要远高于100V的电压。我们认为，在几十伏及更高量级的电压下，小离子通过角质形成细胞和脂质双层的直线路径穿过皮肤。
