鸡冠花中分离得到的一种抗肝毒性多糖——鸡冠花多糖的免疫刺激活性。

Immunostimulating activity of Celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea.

作者信息

Hase K, Basnet P, Kadota S, Namba T

机构信息

Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.

出版信息

Planta Med. 1997 Jun;63(3):216-9. doi: 10.1055/s-2006-957656.

DOI:10.1055/s-2006-957656

PMID:9225602

Abstract

Celosian, an acidic polysaccharide from the seeds of Celosia argenteo (Amaranthaceae) was found to be a potent antihepatotoxic agent for chemical and immunological liver injury models in animals. The immunomodulating action of celosian was studied to clarify the preventive mechanism of celosian on liver injuries. Celosian induced tumor necrosis factor-alpha (TNF-alpha) production in mice. Celosian also induced the production of interleukin-1 beta (IL-1 beta) and nitric oxide (NO) in macrophage cell line J774.1 in a concentration-dependent manner (1 to 1000 micrograms/ml). Moreover, celosian induced IL-1 beta secretion in human mononuclear cells. In addition, celosian enhanced gamma interferon (IFN-gamma) production activity of concanavalin A (Con A) in mice spleen cells, though celosian alone did not significantly influence IFN-gamma production. These results indicate that celosian is an immunostimulating agent in addition to antihepatotoxic effects.

摘要

鸡冠花属植物（苋科青葙种子中的一种酸性多糖）被发现是一种对动物化学性和免疫性肝损伤模型有效的抗肝毒素剂。研究了鸡冠花属植物的免疫调节作用，以阐明其对肝损伤的预防机制。鸡冠花属植物可诱导小鼠产生肿瘤坏死因子-α（TNF-α）。鸡冠花属植物还以浓度依赖的方式（1至1000微克/毫升）诱导巨噬细胞系J774.1产生白细胞介素-1β（IL-1β）和一氧化氮（NO）。此外，鸡冠花属植物可诱导人单核细胞分泌IL-1β。另外，鸡冠花属植物增强了小鼠脾细胞中伴刀豆球蛋白A（Con A）的γ干扰素（IFN-γ）产生活性，尽管鸡冠花属植物单独使用对IFN-γ的产生没有显著影响。这些结果表明，鸡冠花属植物除具有抗肝毒素作用外，还是一种免疫刺激剂。