Andersson M, Bergendorff O, Shan R, Zygmunt P, Sterner O
Division of Organic Chemistry 2, Lund University, Sweden.
Planta Med. 1997 Jun;63(3):251-4. doi: 10.1055/s-2006-957665.
All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.
对有香味没药样品中存在的所有倍半萜进行了分离和表征。获得了七种具有杜松烷、愈创木烷、蛇床烷和桉叶烷骨架的化合物，其中两种是新化合物，两种是首次从天然来源报道的。主要成分T-杜松醇此前已被证明具有平滑肌舒张特性，该研究的主要目的是比较次要的、极性更强的倍半萜与T-杜松醇对大鼠主动脉的作用。与T-杜松醇一样，次要倍半萜在减少钾离子诱导的收缩方面比α-肾上腺素能受体激动剂去氧肾上腺素诱导的收缩更有效，然而，它们的效力都低于T-杜松醇。
