Lysy J, Karmeli F, Sestieri M, Yatzkan Y, Goldin E
Department of Gastroenterology, Hadassah University Hospital, Hebrew University School of Medicine, Jerusalem, Israel.
Metabolism. 1997 Jul;46(7):730-4. doi: 10.1016/s0026-0495(97)90114-1.
Substance P (SP), vasoactive intestinal polypeptide (VIP), and somatostatin content in rectal mucosa were determined by radioimmunoassay (RIA) in 38 diabetic patients (12 with normal bowel function, 13 with diabetic diarrhea, and 13 with constipation) and in 10 nondiabetic controls with normal bowel function. SP content (picograms per milligram) in the rectal mucosa of diabetics with normal bowel function was significantly higher than that of nondiabetic controls (P < .05). SP content in the rectal mucosa of diabetics with diabetic diarrhea and constipation was significantly lower than in diabetics with normal bowel habits and nondiabetic controls (P < .05). No differences were found in the rectal mucosa content of VIP and somatostatin between the different groups of diabetics and controls. Diabetic diarrhea is a condition with an intermittent nature and frequently alternates with constipation. Our findings showing low levels of rectal mucosa SP in both conditions suggest a possible common role of SP in the pathogenesis of diabetic diarrhea and constipation.
采用放射免疫分析法（RIA）测定了38例糖尿病患者（12例肠道功能正常、13例患有糖尿病性腹泻、13例患有便秘）以及10例肠道功能正常的非糖尿病对照者直肠黏膜中P物质（SP）、血管活性肠肽（VIP）和生长抑素的含量。肠道功能正常的糖尿病患者直肠黏膜中的SP含量（皮克/毫克）显著高于非糖尿病对照者（P < 0.05）。患有糖尿病性腹泻和便秘的糖尿病患者直肠黏膜中的SP含量显著低于肠道习惯正常的糖尿病患者及非糖尿病对照者（P < 0.05）。不同组的糖尿病患者和对照者之间，直肠黏膜中VIP和生长抑素的含量未发现差异。糖尿病性腹泻具有间歇性，且常与便秘交替出现。我们的研究结果表明，在这两种情况下直肠黏膜SP水平较低，提示SP在糖尿病性腹泻和便秘的发病机制中可能具有共同作用。
