Garcia M M, Charlton K M, McKay K A
Can J Microbiol. 1977 Oct;23(10):1465-77. doi: 10.1139/m77-215.
Liver abscesses were induced in male albino mice within 1 week after intraperitoneal inoculation of viable Fusobacterium necrophorum LA19 culture. Fusobacteremia was transitory and reached a peak 2 h after inoculation then sharply declined until its disappearance 24 h post inoculation. By contrast, the number of fusobacteria in the liver increased rapidly during the first 4 h post inoculation and continued to do so less rapidly until the last sampling time (48 h post inoculation). There were small or large areas of necrosis, usually surrounded by inflammatory cells, small focal accumulations of lymphocytes, plasma cells, and macrophages in areas of parenchyma with no degenerations, generalized proliferation of Kupffer cells, and a few accumulations of fibrin and leukocytes on the surface. Ultrathin sections of infected liver tissues reveled both intact and partially degraded F. necrophorum cells enclosed in phagocytic and digestive vacuoles of mononuclear cells, The results indicate that macrophages play a key role in the pathogenesis of liver abscesses.
在雄性白化小鼠腹腔内接种坏死梭杆菌LA19活菌培养物后1周内诱发肝脓肿。菌血症是短暂的，接种后2小时达到峰值，然后急剧下降，直到接种后24小时消失。相比之下，接种后前4小时肝脏中梭杆菌数量迅速增加，并在最后采样时间（接种后48小时）之前继续缓慢增加。存在小面积或大面积坏死，通常被炎性细胞包围，在实质区域有小灶性淋巴细胞、浆细胞和巨噬细胞聚集，无变性，库普弗细胞普遍增生，表面有少量纤维蛋白和白细胞聚集。感染肝脏组织的超薄切片显示，单核细胞的吞噬和消化液泡中既有完整的也有部分降解的坏死梭杆菌细胞。结果表明，巨噬细胞在肝脓肿的发病机制中起关键作用。
