Kimpara T, Takeda A, Watanabe K, Itoyama Y, Ikawa S, Watanabe M, Arai H, Sasaki H, Higuchi S, Okita N, Takase S, Saito H, Takahashi K, Shibahara S
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Hum Genet. 1997 Jul;100(1):145-7. doi: 10.1007/s004390050480.
Oxidative stress has been suggested to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Heme oxygenase-1 (HO-1), a key enzyme in heme catabolism, also functions as an antioxidant enzyme. Here, we show that a (GT)n repeat in the human HO-1 gene promoter region is highly polymorphic, although no particular alleles are associated with AD or PD. This newly identified genetic marker should allow us to study the possible involvement of HO-1 in certain human diseases.
氧化应激被认为与神经退行性疾病如阿尔茨海默病（AD）和帕金森病（PD）的发病机制有关。血红素加氧酶-1（HO-1）是血红素分解代谢中的关键酶，也作为一种抗氧化酶发挥作用。在此，我们表明人类HO-1基因启动子区域的（GT）n重复具有高度多态性，尽管没有特定的等位基因与AD或PD相关。这个新发现的遗传标记应该能让我们研究HO-1在某些人类疾病中的可能作用。
