Shimizu H, Shimomura Y, Hayashi R, Ohtani K, Sato N, Futawatari T, Mori M
First Department of Internal Medicine, Gunma University School of Medicine, Japan.
Int J Obes Relat Metab Disord. 1997 Jul;21(7):536-41. doi: 10.1038/sj.ijo.0800437.
The obese (ob) gene encodes leptin which inhibits appetite and stimulates thermogenesis. Serum leptin concentrations are determined by total body fat mass, but the influence of visceral fat accumulation and other metabolic factors have been clinically determined.
We determined the correlations between serum leptin concentrations and the total body fat mass, abdominal fat mass, abdominal fat distribution (estimated by ultrasound), and circulating metabolic factors in 104 Japanese healthy subjects (11 men and 93 women). In addition, the effect of food restriction (30 kcal/kg desired body weight/day) for four weeks on serum leptin concentrations were also examined in 30 women.
There was a significant correlation between serum concentrations and total body fat mass (r = 0.708, P < 0.0001), the percentage of body fat (r = 0.561, P < 0.001), and the body mass index (BMI, r = 0.630, P < 0.001). Serum leptin concentrations were correlated with abdominal wall preperitoneal and subcutaneous fat pad thickness, but not the abdominal wall fat index (AFI). Serum leptin concentrations were also correlated with serum immunoreactive insulin (IRI), but not glucose, or free fatty acid (FFA) concentrations. The weight loss after food restriction for four weeks significantly (P = 0.016) reduced the serum leptin concentrations with a significant reduction of body fat mass, serum glucose, IRI and FFA concentrations. However, there was no significant correlation of the percentage change in serum leptin concentrations to that in body fat mass after food restriction.
Serum leptin concentrations are well correlated with total body fat mass in healthy subjects. Differences in abdominal fat distribution do not appear to be related to a difference in the in vivo leptin production from adipose tissue.
肥胖（ob）基因编码瘦素，瘦素可抑制食欲并刺激产热。血清瘦素浓度由总体脂肪量决定，但内脏脂肪堆积及其他代谢因素的影响已通过临床研究确定。
我们测定了104名日本健康受试者（11名男性和93名女性）血清瘦素浓度与总体脂肪量、腹部脂肪量、腹部脂肪分布（通过超声估算）及循环代谢因子之间的相关性。此外，还对30名女性进行了为期四周的食物限制（30千卡/千克理想体重/天）对血清瘦素浓度影响的研究。
血清浓度与总体脂肪量（r = 0.708，P < 0.0001）、体脂百分比（r = 0.561，P < 0.001）和体重指数（BMI，r = 0.630，P < 0.001）之间存在显著相关性。血清瘦素浓度与腹壁腹膜前和皮下脂肪垫厚度相关，但与腹壁脂肪指数（AFI）无关。血清瘦素浓度还与血清免疫反应性胰岛素（IRI）相关，但与血糖或游离脂肪酸（FFA）浓度无关。四周食物限制后的体重减轻显著（P = 0.016）降低了血清瘦素浓度，同时体脂量、血清葡萄糖、IRI和FFA浓度也显著降低。然而，食物限制后血清瘦素浓度的变化百分比与体脂量的变化百分比之间无显著相关性。
健康受试者血清瘦素浓度与总体脂肪量密切相关。腹部脂肪分布的差异似乎与脂肪组织体内瘦素产生的差异无关。
