Kehrt R, Becker M, Brösicke H, Krüger N, Helge H
Department of Pediatrics, Virchow-Klinikum, Humboldt University, Berlin, Germany.
J Pediatr Gastroenterol Nutr. 1997 Jul;25(1):84-8. doi: 10.1097/00005176-199707000-00014.
The impairment of gastric acid barrier caused by Helicobacter pylori (H. pylori) at the onset of infection may predispose to small bowel bacterial overgrowth, which could contribute to persistent diarrhea.
Using the 13C-urea breath test, we determined the prevalence of H. pylori infection in 123 Nicaraguan children from Tipitapa, aged 1 to 65 months, from a low socioeconomic background.
The overall prevalence of H. pylori infection was 77.2% (95/123). The prevalence varied with age and was significantly (p < 0.001) higher in infants < or = 12 months than in children aged 13-65 months, 91% (57/63) as against 63% (38/60). H. pylori infection was present in 44 of 59 (75%) children suffering from persistent diarrhea compared with 51 of 64 (80%) age-matched asymptomatic controls. In the diarrheal group, 20 of 59 (34%) children presented with malnutrition, and 16 (80%) of them showed H. pylori infection. In the control group, 20 of 64 (31%) were malnourished, and 14 (70%) of them showed H. pylori infection.
In Nicaragua, H. pylori is acquired in early infancy. The high prevalence among children in the first 12 months of life and the lower infection rate between 1 and 5 years of age suggest a loss or clearance of infection, also an occasional finding in adults. H. pylori infection appears to be not a risk factor for persistent diarrhea or malnutrition in Nicaraguan children.
幽门螺杆菌（H. pylori）感染初期导致的胃酸屏障受损可能易引发小肠细菌过度生长，进而导致持续性腹泻。
我们采用13C - 尿素呼气试验，测定了来自蒂皮塔帕、年龄在1至65个月、社会经济背景较低的123名尼加拉瓜儿童的幽门螺杆菌感染率。
幽门螺杆菌感染的总体患病率为77.2%（95/123）。患病率随年龄变化，12个月及以下婴儿的患病率（91%，57/63）显著高于13 - 65个月儿童（63%，38/60）（p < 0.001）。59名持续性腹泻儿童中有44名（75%）感染幽门螺杆菌，而64名年龄匹配的无症状对照儿童中有51名（80%）感染。在腹泻组中，59名儿童中有20名（34%）出现营养不良，其中16名（80%）感染幽门螺杆菌。在对照组中，64名儿童中有20名（31%）营养不良，其中14名（70%）感染幽门螺杆菌。
在尼加拉瓜，幽门螺杆菌在婴儿早期获得。1岁前儿童中的高患病率以及1至5岁儿童较低的感染率表明感染有所减少或清除，这在成人中也偶尔可见。幽门螺杆菌感染似乎不是尼加拉瓜儿童持续性腹泻或营养不良的危险因素。
