Woodhead D, Setlow R B, Hart R W
Cancer Res. 1977 Dec;37(12):4261-6.
In previous studies a clone of the gynogenetic fish, Poecilia formosa (the Amazon molly), was successfully used as a test animal to identify ultraviolet-induced damage. This work has been extended, and the fish system was used to detect damage caused byionizing radiation. Fish cells, exposed in vitro to 250 and 500 rads, were injected into young isogenic recipients, and 9 months later the fish were examined grossly and histologically. Two of the most conspicuous changes that resulted were the development of extensive invasive thyroid hyperplasia and hypertrophy body, with an apparent reduction in the amount of hemato-poietic tissue in the head kidney and spleen. We discuss the difference between the responses of the recipient fish to cells exposed to ionizing radiation and to cells exposed to ultraviolet light.
在之前的研究中，雌核发育鱼类——帆鳉（又称亚马逊帆鳉）的一个克隆品系被成功用作实验动物，以识别紫外线诱导的损伤。这项工作得到了拓展，该鱼类系统被用于检测电离辐射造成的损伤。将体外暴露于250拉德和500拉德辐射的鱼细胞注射到同基因的幼体受体中，9个月后对鱼进行大体和组织学检查。所导致的两个最显著变化是广泛侵袭性甲状腺增生和身体肥大，同时头肾和脾脏中的造血组织数量明显减少。我们讨论了受体鱼对暴露于电离辐射的细胞和暴露于紫外线的细胞的反应差异。
