Ball M A, Rebhun W C, Gaarder J E, Patten V
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
J Am Vet Med Assoc. 1997 Jul 15;211(2):199-203.
To evaluate the efficacy of itraconazole-dimethyl sulfoxide ointment for treatment of keratomycosis in horses in the northeastern United States.
Prospective clinical trial.
9 horses (10 affected eyes).
All horses treated for keratomycosis at Cornell University between July 1994 and July 1996 were included in the study. The diagnosis of keratomycosis was confirmed by cytologic examination, and all horses were treated with 0.25 ml of a 1% itraconazole-30% dimethyl sulfoxide petrolatum-based ointment, applied to the affected eye every 4 hours.
Topical application of itraconazole-dimethyl sulfoxide ointment (q 4 h) resolved keratomycosis in 8 of 10 eyes; mean duration of treatment was 34.6 days (range, 16 to 53 days).
Results of this study indicate topical administration of itraconazole-dimethyl sulfoxide ointment may provide an additional treatment option for horses with keratomycosis.
评估伊曲康唑-二甲基亚砜软膏治疗美国东北部马匹角膜真菌病的疗效。
前瞻性临床试验。
9匹马（10只患眼）。
纳入1994年7月至1996年7月间在康奈尔大学接受角膜真菌病治疗的所有马匹。通过细胞学检查确诊角膜真菌病，所有马匹均用0.25毫升1%伊曲康唑-30%二甲基亚砜凡士林基软膏，每4小时涂于患眼。
伊曲康唑-二甲基亚砜软膏局部应用（每4小时一次）使10只眼中的8只角膜真菌病痊愈；平均治疗时间为34.6天（范围16至53天）。
本研究结果表明，局部应用伊曲康唑-二甲基亚砜软膏可为患角膜真菌病的马匹提供一种额外的治疗选择。
