Tseleni-Balafouta S, Grigorakis S I, Alevizaki M, Karaiskos C, Davaris P, Koutras D A
Athens University Department of Medical Therapeutics, Alexandra Hospital, Greece.
Gen Diagn Pathol. 1997 Jun;142(5-6):371-4.
We present the case of a patient in whom we diagnosed two different thyroid carcinomas (one on each lobe) of distinct histologic type: one derived from the follicular cells (papillary) and one from the C cells (medullary). They were both diagnosed preoperatively by fine needle aspiration (FNA), and the diagnosis was confirmed with histologic examination. "Inappropriate" staining with neuroendocrine markers was observed in the papillary tumor. Analysis of tumor tissue for the RET oncogene mutations, commonly found in the MEN2 syndromes, was negative. This case supports the view of a common origin for these two tumor types.
我们报告了一例患者，在该患者中我们诊断出两种不同组织学类型的甲状腺癌（每个叶各一个）：一种源自滤泡细胞（乳头状），另一种源自C细胞（髓样）。二者均通过细针穿刺抽吸术（FNA）在术前得到诊断，且诊断经组织学检查得以证实。在乳头状肿瘤中观察到神经内分泌标志物的“不适当”染色。对RET原癌基因突变进行分析，该突变常见于MEN2综合征，结果为阴性。此病例支持这两种肿瘤类型具有共同起源的观点。
