Cormio L, La Forgia P, La Forgia D, Siitonen A, Ruutu M
Department of Urology, Helsinki University Central Hospital, Finland.
Urol Res. 1997;25(3):213-6. doi: 10.1007/BF00941985.
The aim of this study was to determine whether the use of bactericidal coatings or immersion in antibiotic solution reduces or prevents bacterial adhesion onto ureteric stents. Precut segments of full silicone, silver-coated and hydrogel-coated ureteric stents were incubated with two uropathogenic bacterial strains with and without previous immersion in antibiotic solution. Tobramycin, ceftriaxone and ciprofloxacin solutions were used, as these antibiotics are commonly administered for the prophylaxis and treatment of urinary tract infection (UTI). Microbiological analysis showed that immersion of ureteric stents in ceftriaxone and ciprofloxacin yielded a significant reduction of bacterial adhesion, whereas immersion in tobramycin did not. The surface material of the stents had no direct influence on bacterial adhesion. In this experimental study, neither the silver nor the hydrogel coat reduced bacterial adhesion onto ureteric stents whereas immersion in a suitable antibiotic solution significantly reduced and even prevented this phenomenon, probably due to the adhesion of the antibiotic onto the stent surface. Prevention of bacterial adhesion onto ureteric stents is essential to reduce the risk of UTI in connection with these devices.
本研究的目的是确定使用杀菌涂层或浸泡在抗生素溶液中是否能减少或防止细菌粘附到输尿管支架上。将全硅胶、银涂层和水凝胶涂层输尿管支架的预切片段与两种尿路致病菌株一起孵育，且这些片段有的事先浸泡在抗生素溶液中，有的没有浸泡。使用了妥布霉素、头孢曲松和环丙沙星溶液，因为这些抗生素常用于预防和治疗尿路感染（UTI）。微生物学分析表明，将输尿管支架浸泡在头孢曲松和环丙沙星中可显著减少细菌粘附，而浸泡在妥布霉素中则没有这种效果。支架的表面材料对细菌粘附没有直接影响。在本实验研究中，银涂层和水凝胶涂层均未减少细菌在输尿管支架上的粘附，而浸泡在合适的抗生素溶液中可显著减少甚至防止这种现象，这可能是由于抗生素粘附在支架表面所致。防止细菌粘附到输尿管支架上对于降低与这些装置相关的尿路感染风险至关重要。
