TerWee J, Lauritzen A Y, Sabara M, Dreier K J, Kokjohn K
Pfizer Central Research, Lincoln, NE 68521, USA.
Vet Microbiol. 1997 May;56(1-2):33-45. doi: 10.1016/S0378-1135(96)01344-2.
Two strains of feline calicivirus, one reportedly pneumotrophic (FPV 255) and the other associated with a limping syndrome (2280) were compared with respect to the signs induced in kittens after oronasal exposure. Neither strain induced severe upper respiratory symptoms, and both caused oral ulcers and lameness. However oral ulcers were more prevalent, and lameness and depression were more pronounced in the kittens which received strain 2280. Kittens which exhibited lameness also had elevated blood levels of alpha 1-acid glycoprotein. A decline in lymphocyte count was noted only in kittens which received strain 2280. These data demonstrate that despite reported antigenic and genetic differences between these strains, no distinct differences in pathogenicity could be determined.
对两株猫杯状病毒进行了比较，一株据报道具有嗜肺性（FPV 255），另一株与跛行综合征有关（2280），比较了它们经口鼻腔暴露后在小猫身上引发的症状。两株病毒均未诱发严重的上呼吸道症状，且都导致口腔溃疡和跛行。然而，口腔溃疡更为普遍，在接种2280株病毒的小猫中，跛行和抑郁更为明显。出现跛行的小猫血液中α1-酸性糖蛋白水平也升高。仅在接种2280株病毒的小猫中观察到淋巴细胞计数下降。这些数据表明，尽管报道称这些毒株之间存在抗原性和基因差异，但在致病性方面未发现明显差异。
