Kita K, Hirawake H, Takamiya S
Department of Parasitology, University of Tokyo, Japan.
Int J Parasitol. 1997 Jun;27(6):617-30. doi: 10.1016/s0020-7519(97)00016-7.
Parasitic helminths exhibit greater diversity in energy metabolism than do the host animals and many have exploited unique respiratory chains as adaptations to their natural habitats. Cytochromes are involved, not only in intracellular aerobic respiration found in free-living stages, but also in the reduction of relatively oxidized compounds such as fumarate during the adult stages of parasitic helminths. In addition, most helminths retain a significant capacity to produce energy via aerobic pathways and have a mammalian type respiratory chain in their mitochondria during their development in the host. In this review, we focus on recent advances in the study of cytochromes in the respiratory chain of parasitic helminths. These include the identification of unique features of anaerobic respiration in adult parasites, the elucidation of molecular structures of the components involved and an understanding of the developmental changes that occur during the life-cycle of these parasites.
寄生性蠕虫在能量代谢方面表现出比宿主动物更大的多样性，许多寄生性蠕虫利用独特的呼吸链来适应其天然栖息地。细胞色素不仅参与自由生活阶段的细胞内有氧呼吸，还参与寄生性蠕虫成虫阶段相对氧化的化合物（如富马酸）的还原。此外，大多数蠕虫在宿主体内发育过程中，通过有氧途径产生能量的能力很强，并且其线粒体中具有哺乳动物类型的呼吸链。在这篇综述中，我们重点关注寄生性蠕虫呼吸链中细胞色素研究的最新进展。这些进展包括确定成虫寄生虫厌氧呼吸的独特特征、阐明相关成分的分子结构以及了解这些寄生虫生命周期中发生的发育变化。
