Wertheimer R, Blessmann G
Augenklinik Rechts der Isar der Technischen Universität München.
Klin Monbl Augenheilkd. 1997 Feb;210(2):93-6. doi: 10.1055/s-2008-1035023.
Allergic conjunctivitis is one of the most frequent allergic diseases of the anterior eye segment.
This multicentre, clinical trial was an investigation to compare the antiallergic efficacy, local tolerance and safety of Antazolin/Tetryzolin eye drops and Levocabastine eye drops. 69 patients were treated over a 2 weeks course of therapy. The subjective and objective ocular symptoms were documented over the treatment period.
Both eye drops reduced subjective and objective ocular symptoms effective. The difference between the treatments (p = 0.0395) was the faster onset of action of Antazolin/Tetryzolin 30 minutes after administration of the first drop of trial medication.
A fast and effective onset of action is of high clinical relevance. Therefore the benefits of using Antazolin/Tetryzolin eye drops was clearly outweigh.
过敏性结膜炎是眼前段最常见的过敏性疾病之一。
这项多中心临床试验旨在比较安他唑啉/四氢唑啉滴眼液和左卡巴斯汀滴眼液的抗过敏疗效、局部耐受性和安全性。69名患者接受了为期2周的治疗。在治疗期间记录主观和客观眼部症状。
两种滴眼液均有效减轻主观和客观眼部症状。治疗之间的差异（p = 0.0395）在于，在滴入第一滴试验药物后30分钟，安他唑啉/四氢唑啉起效更快。
快速有效的起效具有高度临床相关性。因此，使用安他唑啉/四氢唑啉滴眼液的益处明显更大。
