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[光动力疗法、激光疗法、近距离放射疗法、支架。肺癌的局部控制]

[Photodynamic therapy, laser therapy, brachytherapy, stents. Local control of lung cancer].

作者信息

Hillerdal G

机构信息

Lungkliniken, Karolinska sjukhuset, Stockholm.

出版信息

Lakartidningen. 1997 Jun 18;94(25):2377-9, 2380.

PMID:9229658
Abstract

As only a small proportion of patients presenting with lung cancer can be cured, palliation has a very important place in their treatment. The local effects of lung cancer often entail substantial deterioration of the patient's quality of life. Recent advances in such techniques as laser treatment, brachytherapy, photodynamic therapy and prosthetic stents have enabled important improvements to be made in the control of lung cancer (both primary tumours and metastases). Laser treatment is mainly used to obtain bronchial patency rapidly, but needs to be followed up with other treatments. Photodynamic therapy is confined to the treatment of very small early cancers, but may be curative in such cases. Brachytherapy, the brief introduction of a source of radiation in the bronchi, may be effective both in endobronchial tumours, and in cases where there is compression due to a tumour outside the bronchi. The method can be used repeatedly, even in patients undergoing external beam radiation therapy. Finally, prosthetic stents are increasingly used to maintain bronchial patency, both in malignant and in certain non-malignant diseases. The achievement of optimal results often entails the use of a combination of the various methods, thus necessitating close cooperation between lung specialists, oncologists, radiologists, ENT surgeons and GPs.

摘要

由于仅有一小部分肺癌患者能够治愈,姑息治疗在其治疗中占有非常重要的地位。肺癌的局部影响常常导致患者生活质量严重下降。激光治疗、近距离放射治疗、光动力疗法和人工支架等技术的最新进展已使肺癌(原发性肿瘤和转移瘤)的控制取得了重要进展。激光治疗主要用于迅速实现支气管通畅,但需要后续采用其他治疗方法。光动力疗法仅限于治疗非常小的早期癌症,但在此类病例中可能具有治愈效果。近距离放射治疗,即将放射源短暂引入支气管,对支气管内肿瘤以及支气管外肿瘤压迫的情况可能均有效。该方法可重复使用,即使是接受外照射放疗的患者。最后,人工支架越来越多地用于维持支气管通畅,无论是在恶性疾病还是某些非恶性疾病中。要取得最佳效果往往需要联合使用多种方法,因此肺部专科医生、肿瘤学家、放射科医生、耳鼻喉科外科医生和全科医生之间需要密切合作。

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